Inclusion Criteria:

- Subject (or authorized legal representative) who can provide written informed consent
before beginning any study procedure.

- Understand and agree to abide by the study procedures.

- Adult #18 years of age at the time of inclusion in the study.

- Confirmation of SARS-CoV-2 infection by a microbiological test performed before
randomization, no longer than 72 hours.

- Severity 3-4 according to the WHO 7-point ordinal scale.

Exclusion Criteria:

- ALT / AST> 5 times the normal limit

- Stage 4 chronic kidney disease (GFR <30) or requiring dialysis.

- Presence of comorbidities that imply a poor prognosis (according to clinical
judgment).

- Advanced dementia.

- Pregnancy or breastfeeding.

- Anticipation of transfer to another center in the 12 hours at the beginning of the
study.

- Allergy to study medication.

- Serious or active bacterial infections or documented sepsis by pathogens other than
SARS-CoV-2.

- Streptococcus pneumoniae antigenuria positive before study start.

- Neutropenia <500 / mm3.

- Thrombocytopenia <100,000 / mm3.

- History of diverticulosis.

- Ongoing skin infection (eg, pyodermitis).

- Transplanted patient under immunosuppressive treatment.

- Previous evidence of latent untreated tuberculosis.