The first version of this preprint article is registered on the 4th of May 2020 under the digital object identifier of:10.31219/osf.io/u56fc. COVID-19 infections virus spread worldwide and impact many countries with sever economical sequences. The effective antiviral medication or vaccination for the virus is unavailable until the present date and it takes months or years to discover the effective treatment or test the efficacy of the discovered treatment. Based on these facts, the human immune system against the virus may have an effective role to regulate the infection and reduce the mortality rate among the infected patients. This proposed research article aims to explore the available medication/ natural supplementation to boost the immunity system of the patients against COVID-19 infections and reduce the mortality rate among infected patients. Methods: a proposed clinical trial will be carried out to investigate the effect of the different treatment modalities on the human immune system against COVID-19 infection.
Natural supplementations have many reported effects on the human health ranged from immunity
boosting to effective antiviral effect. Omeg-3 as an example affect the human health by many
mechanisms e.g. Anti-oxidant, immunity boosting agent. Moreover, Omega-3 exerts an antiviral
effect on Flu virus by inhibiting influenza virus replication 1. On the other hand, black
seed supplementation exerts a chelation effect on sickle cell anemia patients and inhibits
Human Heme Metabolism 2. Moreover, black seed exerts an antiviral effect on the replication
of old coronavirus and the expression of (TRP-genes) family 3. In addition, Omega-3 regulates
the human immunity against bacterial and viral infections 4. During the past years, many
natural sources exerts an antimalarial effect with perfect reported results 5.
Drug: Omega 3/Nigella Sativa Oil
Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Drug: Omega 3/Nigella Sativa Oil/Indian Costus
Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Indian Costus supplements
Drug: Omega 3/Nigella Sativa Oil/Quinine pills
Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Quinine supplementation (1g Quinine)
Drug: Omega 3/Nigella Sativa Oil/Anise seed capsule
Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Anise seed supplementation (450mg anise seed)
Drug: Omega 3/Nigella Sativa Oil/Deglycyrrhizinated Licorice
Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Deglycyrrhizinated Licorice 800 mg
Drug: Active Comparator
Standard protocol care of COVID-19 infection
Inclusion Criteria:
- Symptomatic with respiratory or systemic symptoms
- Positive nasopharyngeal swab for COVID-19
- CT imaging showing viral pneumonia
- Temperature 38°C
- Respiratory rate < 25 /min
- Oxygen saturation (pulse oximetry) >95%
Exclusion Criteria:
- Pregnant or breast feeding
- Hepatic failure Child-Pugh C
- Negative swab test of (SARS)-(CoV-2)
- Expected life is less than 24 hours
- End-stage lung disease
Maternity and Children hospital
Mecca, Makkah, Saudi Arabia