The purpose of this study is to describe the long-term health effects of COVID-19 in apopulation of mostly Black and Latinx individuals and their households who were diagnosedwith COVID-19 at Columbia University Irving Medical Center. In New York, the upperManhattan and south Bronx communities neighboring Columbia University Irving MedicalCenter (CUIMC) have been two of the most impacted communities of the COVID-19 pandemic.These neighborhoods are predominantly non-Hispanic black or African American and Latinx.This study will invite people who tested positive for COVID-19 and/or were treated atColumbia University Irving Medical Center to: 1) take a survey to ask about currentsymptoms and any health problems and 2) ask permission to review COVID-related healthhistory including COVID-19 testing results (from the medical record) since infection tolearn about health effects after COVID-19 infection; 3) invite anyone in their householdto take a survey; and 4) for up to 500 patients who were hospitalized for COVID, give theoption of doing a nasal swab to test for SARS-CoV-2 virus and blood test to check forantibody up to 12 months after diagnosis, to compare how results are different 12 monthsafter infection. The goal is to learn about how the severity of person's infection in2020 influences long term health effects and how others in their household are impactedby COVID-19.
The goal of this study is to describe long-term outcomes of COVID-19 in a predominantly
Black and Latinx community. The investigators propose to recruit patients who were
diagnosed with and/or treated for COVID-19 at CUIMC. The investigators seek to
characterize the long-term outcomes of the patients and their households. The catchment
community and patient population accessing CUIMC is predominantly Black and Latinx. The
investigators will approach individuals who were treated for COVID at CUIMC in order to:
administer an online questionnaire to collect information about presence of long-term
sequalae or complications after initial infection (mental health, cardiovascular,
pulmonary, neurological, as well as impact on activities of daily of living); with
participant's permission, obtain data from the electronic medical record about initial
testing results, inflammatory markers, post-diagnosis events such as re-admissions,
clinic visits, and treatments for cardiovascular, pulmonary, neurological complications
related to COVID; the investigators will also invite interested household members to
complete out a on-line questionnaire with an option to review their electronic medical
record for information related to COVID-19 testing and diagnosis. For a subset of
individuals who were admitted to the hospital at the time of initial diagnosis the
investigators will invite them to submit a follow-up nasal swab (for polymerase chain
reaction (PCR) and sequencing) and blood sample (to measure antibodies) to assess for
re-infection and change in the molecular epidemiology of the SARS-CoV-2. The
investigators hypothesize that the baseline clinical, serological and molecular responses
to COVID-19 will be characterized by demographic markers such as age, sex, racial and
ethnic identity of families and households. Furthermore, the investigators hypothesize
that baseline inflammatory and virologic phenotype of the individual (as defined by
levels of plasma inflammatory markers and SARS-COV-2 viral load in nasopharyngeal swabs)
will have an impact on clinical outcomes and overall status following infection and the
investigators will examine the role of these factors in the cohort. The investigators
will partner with community based organizations and community stakeholders, to
dissemination information about this study and to communicate results back to the
communities.
Other: Survey
Survey completion by the participant to collect information about health and social
experience
Other: Medical History Review
Review of the participant's medical history at New York Presbyterian/Columbia University
Irving Medical Center
Other: Sample Collection
Collection of nasal and blood samples
Inclusion Criteria - Objective 1 Participants:
1. age 18 years and older
2. having an electronic medical record at NYP
3. laboratory confirmed COVID-19 infection diagnosed at NYP/CUIMC after March 1, 2020
or were diagnosed at least 9 months prior to administration of the online
questionnaire on long-term outcomes and sequelae.
4. Able to provide informed consent
Exclusion Criteria -
1. Index cases less than 18 years of age.
2. Not COVID-19 diagnosed
Inclusion Criteria - Objective 2 Participants:
1. age 18 years and older
2. having an electronic medical record at NYP
3. Hospitalized at NYP/CUIMC after March 1 2020, or at least 9 months prior to
administration of the online questionnaire on long-term outcomes and sequelae
4. Randomly selected: every 10th index case who was not hospitalized
5. Able to provide informed consent AND
6. Are willing to provide a nasal swab, blood sample in addition to completing the
questionnaire.
Columbia University Irving Medical Center
New York, New York, United States
Investigator: Tae Kim
Contact: 845-372-5023
covid19idresearch@cumc.columbia.edu
Magda Sobieszczyk, MD
(845) 372-5023
covid19idresearch@cumc.columbia.edu