During the pandemic, people are anxious for information, and electronic platform servesthe purpose of having first-hand health information and spreading it to massivepopulation within a short time. However, the source and credibility of the influx ofonline information are hard to be verified. Digital health literacy (DHL) is the capacityto access, understand, evaluate, and apply health information from electronic sources,which is an important attribute that everyone should possess. Recent studies from ourgroup in Hong Kong have shown that, during the COVID-19 pandemic, DHL is an issue facingpeople of all ages, especially ethnic minorities (EMs), people with chronic illnesses(PWCI), and professional and lay caregivers (CGs). Considering that, the present researchproject aims to co-create DHL interventions with these three groups of people to meettheir specific needs in DHL, in addition, to assess the efficacy of the DHL interventionson eHealth literacy, vaccine literacy, and actions taken for COVID-19 prevention. Thepresent research is a 4-year project, involving three phases. Phase 1 involves focusgroup interviews and cognitive interviews with the three groups of people for developinginterventions and evaluating the proposed interventions. Phase 2 involves individualinterviews with the three groups of people for testing the feasibility and acceptabilityof the interventions. Phase 3 involves a 6-month longitudinal quantitative research,testing for the efficacy of the interventions in three dimensions: literacy, attitude,and behavior. Participants from the three groups will be invited to join virtual orface-to-face training, watch short videos on social media, participate in virtualbi-weekly group discussion, and fill in questionnaires for five times during the courseof the study. This co-creation of new knowledge by stakeholders and researchers isexpected to increase the uptake of the research outcomes and adoption of the DHLinterventions.