Official Title
Vitamin D3, Mouthwash, Saliva Testing, Covid-19, Antiviral Testing
Brief Summary

The PI's goal of this [interventional/clinical trial] is to [explore the antiviralproperties of vitamin D3 on saliva samples collected before and after the use of avitamin D3 mouthwash] in [ adult participants, both genders, with COVID-19 who testedpositive on a swab test]. The main question[s] aims to answer [is]:[Assess the antiviral potential of a novel vitamin D-based mouthwash in COVID-19-positiveparticipants].PI will compare both [Control group: saliva only- before use of mouthwash], and the[study group: after use of the mouthwash in saliva] to see if there is [any veridicaleffect present in saliva after running lab tests].Participants will [self-collect saliva in a given tube (color coded orange), then 10-15minutes later or more, participants will swish with D3 mouthwash, and will give anothersample [saliva + mouthwash] in another (green labeled tube). For each participant, eachof the following will be given: - 2 collecting tubes: orange labeled tube (for saliva collection only) and green labeled tube (for saliva collection after mouthwash use). - The vial containing vitamin D3 mouthwash.

Detailed Description

Twenty-five adult participants confirmed COVID-19-positive, via rapid antigen testing
(RAT) thru nasal swabs (NS), followed by saliva samples collected before and after using
a vitamin D3 mouthwash. Samples were analyzed using RAT and rapid polymerase chain
reaction (R-PCR) to measure viral load.

Completed
Corona Virus Disease 19 (COVID-19)

Drug: Cholecalciferol (vitaminD3)

Vitamin D3 mouthwash was prepared for COVID-19 participants, to compare between the
saliva only (control group), and with the use of mouthwash in saliva after the
participants swish for 60 seconds (experimental group) and compare the effect of vitamin
D over the virus in saliva, from both groups by testing via RAT and R-PCR.

Eligibility Criteria

Inclusion criteria:

- Adult participants confirmed positive for COVID-19 by RAT.

- Participants at the King Faisal Specialist Hospital & Research Center in Jeddah
(KFSHRC, J) outpatient departments (OPD) and/or department of emergency medicine
(DEM).

Exclusion criteria:

- Immunocompromised and/or pregnant participants.

- Pediatric participants and patients aged <18 years.

- Participants on a high-dose vitamin D prescription (i.e., 10, 000 IU or more).

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Saudi Arabia
Locations

KingFaisal
Jeddah, Saudi Arabia

Not Provided

King Faisal Specialist Hospital & Research Center
NCT Number
MeSH Terms
COVID-19
Virus Diseases
Cholecalciferol
Vitamin D