Autoimmune diseases are disorders of the body's immune function, involving multiple
organs and tissues of the whole body, and characterized by a variety of specific or
non-specific autoantibodies and inflammatory factors overexpression. However, during the
global COVID-19 pandemic, patients with autoimmune diseases, especially those receiving
immunosuppressive therapy, face a high burden of novel coronavirus pneumonia (COVID-19)
and are at higher risk for severe infection and disease progression. At present, patients
with autoimmune diseases should give priority to the prevention and treatment strategy of
COVID-19, among which the vaccination of novel coronavirus vaccine is the most important
means to actively build herd immunity and control the epidemic of novel coronavirus
pneumonia, and the combination of traditional Chinese and western medicine is an
essential and effective way to prevent and treat COVID-19 infection. According to the
comprehensive evaluation, the completion of vaccination and the prevention and treatment
strategy of integrated traditional Chinese and western medicine have obvious advantages
in improving the symptoms of infection in patients with autoimmune diseases, shortening
the course of disease and controlling disease activity, and can play a positive role in
the whole process of epidemic prevention and treatment. Now the investigators plan to
conduct multi-center clinical and basic research to observe the preventive effect and
safety of the vaccine on COVID-19, as well as the preventive effect of the combination of
traditional Chinese medicine, in order to obtain high-quality evidence-based evidence and
provide scientific basis for the clinical value of the drug.