This is a Phase 4, post-market US study, evaluating the efficacy and safety of a singledose of the NVX-CoV2705 Omicron JN.1 COVID-19 vaccine. Approximately 6,500 healthy adultsaged 50 to under 65 will be randomized to receive either the vaccine or a placebo, withfollow-up for 180 days.
This is a Phase 4, multicenter, randomized, double-blind, placebo-controlled,
post-marketing study to evaluate the efficacy and safety of a single dose of an Omicron
JN.1 subvariant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant
(r) spike (S) protein nanoparticle vaccine (SARS-CoV-2 rS) adjuvanted with Matrix-M
(NVX-CoV2705) in adults 50 to < 65 years of age who are not considered to be at high risk
of severe coronavirus disease 2019 (COVID-19). This study will be conducted in the United
States (US).
Approximately 6,500 participants will be randomized in a 1:1 ratio via block
randomization to receive a single intramuscular (IM) injection of NVX-CoV2705 or placebo
(normal saline) on Day 0 and remain on study for efficacy and safety data collection
through Day 180/end of study (EoS).
Biological: NVX-CoV2705
NVX-CoV2705 vaccine in a 0.5 mL injection volume at an antigenic dose of 5 µg with 50 µg
Matrix-M adjuvant
Other Name: Omicron JN.1 subvariant SARS-CoV-2 rS vaccine adjuvanted with Matrix-M
Biological: Placebo
Placebo (normal saline) in a 0.5 mL injection volume.
Inclusion Criteria:
- To be included in this study, each individual must satisfy all of the following
criteria:
1. Adults 50 to < 65 years of age at time of study vaccination (Day 0) who are not
considered to be at high risk of severe COVID-19.
2. Participants unvaccinated to SARS-CoV-2 or participants previously vaccinated
with a COVID-19 vaccine ≥ 90 days prior to study vaccination.
3. Participant or legally acceptable representative is willing and able to give
informed consent prior to study enrollment and to comply with study procedures.
4. Female participants of childbearing potential (defined as any participant who
has experienced menarche and who is NOT surgically sterile [ie, hysterectomy,
bilateral tubal ligation, or bilateral oophorectomy] or postmenopausal [defined
as amenorrhea ≥ 12 consecutive months]) must agree to be heterosexually
inactive from at least 28 days prior to enrollment and through 90 days after
vaccination OR agree to consistently use a medically acceptable method of
contraception listed below from ≥ 28 days prior to enrollment and through 90
days after vaccination.
1. Condoms (male or female) with spermicide (if acceptable in country)
2. Diaphragm with spermicide
3. Cervical cap with spermicide
4. Intrauterine device
5. Oral or patch contraceptives
6. Norplant®, Depo-Provera®, or other in country regulatory approved
contraceptive method that is designed to protect against pregnancy
7. Abstinence, as a form of contraception, is acceptable if in line with the
participant's lifestyle NOTE: Periodic abstinence (eg, calendar,
ovulation, sympto-thermal, post-ovulation methods) and withdrawal are not
acceptable methods of contraception.
5. Agrees not to participate in any research involving receipt of investigational
products (drug/biologic/device), including other SARS-CoV-2 prevention or
treatment trials, for the duration of the study.
Exclusion Criteria:
- If an individual meets any of the following criteria, he or she is ineligible for
this study:
1. Is considered to be at high risk of severe COVID-19 due to underlying medical
conditions or risk factors that demonstrated a conclusive increase in risk for
at least one severe COVID-19 outcome, as described by the Centers for Disease
Control and Prevention (CDC) .
2. Unstable acute illness at the time of vaccination.
3. Participation at the time of study enrollment or planned participation during
the present study period in another clinical study investigating a vaccine,
drug, medical device, or medical procedure.
4. Current participation in any other COVID-19 prevention clinical trial.
5. Known history of COVID-19 infection within 90 days of study vaccination.
6. Any known history of allergies to products contained in the investigational
product in the participant's lifetime.
7. Any known history of anaphylaxis to any prior vaccine in the participant's
lifetime.
8. Known history of myocarditis or pericarditis in the participant's lifetime.
9. Chronic administration (defined as > 14 continuous days) of immunosuppressant,
systemic glucocorticoids, or other immune-modifying drugs within 90 days prior
to study vaccination (Day 0).
NOTE: An immunosuppressant dose of glucocorticoid is defined as a systemic dose
≥ 10 mg of prednisone per day or equivalent. The use of topical, inhaled, or
intranasal glucocorticoids is permitted. Topical tacrolimus and ocular
cyclosporin are permitted.
10. Received immunoglobulin or blood-derived products within 90 days prior to study
vaccination (Day 0).
11. Participants who are pregnant, or who plan to become pregnant within 90 days
following study vaccination.
12. Any other condition that, in the opinion of the investigator, would pose a
health risk to the participant if enrolled or could interfere with evaluation
of the study vaccine or interpretation of study results (including neurologic
or psychiatric conditions likely to impair the quality of safety reporting).
13. Study team member or immediate family member of any study team member
(inclusive of Sponsor, clinical research organization [CRO], and study site
personnel involved in the conduct or planning of the study).
Not Provided
Not Provided