cognitive dysfunction, and post-exertional malaise are common complaints of those living
with Post-COVID Condition (PCC), a sequelae of symptoms that persist beyond acute
infection. Similar to other types of post-viral fatigue, the diagnosis and treatment of
PCC are challenging due to the lack of a valid biomarker for the condition. Though the
etiology of PCC is not well understood, recent research has found reduced skeletal muscle
creatine concentration in those with PCC, which may contribute to fatigue. The objective
of this study is to determine if eight weeks of creatine monohydrate supplementation
(8g/day) improves symptoms of fatigue, cognition, exercise capacity, and PEM in
individuals living with PCC.

Participants will complete two cardiopulmonary exercise tests 24-hours apart on a cycle
ergometer before and after an eight-week intervention period. Venous blood samples will
be collected before and after exercise on both days to assess changes in mitochondrial
function. During the intervention, participants will be randomly assigned to supplement
with 8g/day of either creatine monohydrate or a control (maltodextrin). Cognition will be
indirectly assessed via self-report of cognitive symptom frequency and severity at
baseline, mid-intervention (i.e., 4 weeks) and post-intervention.