Inclusion Criteria:

1. Written informed consent.

2. Healthy male or female subjects, as determined by medical history and medical
examination.

3. Aged 18 to 49 years.

4. Subjects who have been vaccinated (2 to 4 doses) with a licensed SARS-CoV-2
(COVID-19) vaccine. The last dose should be >6 months before administration of the
investigational vaccine.

5. Reliable and willing to make themselves available for the duration of the study,
willing and able to follow study procedures.

6. Willing to refrain from strenuous physical exercise during the week preceding any
blood sampling, including between screening and vaccination visit (Visit 2).

Exclusion Criteria:

1. Subjects with a body mass index (BMI) <18 kg/m² or >30 kg/m² at screening.

2. Subjects weighing less than 50 kg.

3. Subjects with abnormal safety laboratory (hematology, biochemistry, coagulation and
urinalysis) parameter at screening.

4. Subjects having previously received a non-licensed SARSCoV-2 vaccine or only one
single dose of a licensed SARSCoV-2 vaccine.

5. Subjects having presented medically significant adverse event after having received
a SARS-CoV-2 licensed vaccine.

6. Subjects currently treated with medications intended to prevent SARS-CoV-2 infection
or disease (COVID-19) complications.

7. SARS-CoV-2 infection within the past 3 months prior to enrolment, RT-PCR-confirmed
SARS-CoV-2 infection at screening or ongoing symptom of COVID-19.

8. Subjects having received another vaccination within 3 months prior to the day of
study vaccination for live attenuated vaccines, or within 1 month prior to the day
of study vaccination for inactivated vaccines.

9. Planning to receive other vaccines during the first 28 days following the study
vaccine administration.

10. Female subjects: pregnant, breast-feeding or of childbearing potential without
appropriate contraceptive methods in place for at least 2 months before enrolment,
or with positive pregnancy test at screening or on the day of vaccination.
Appropriate contraceptive methods are to be maintained until the end of the trial.

11. Subjects receiving treatment that can affect immune response such as systemic or
high dose inhaled corticosteroids (>800μg/day beclomethasone or equivalent;
occasional inhaled corticosteroids for asthma therapy are allowed), radiation
treatment, cytotoxic drugs, or current or recent (within 3 months before study
entry) chronic or prolonged (>10 days) use of systemic non-steroidal
anti-inflammatory drugs, interferon, immunomodulators, allergy shots, as judged by
the Investigator.

12. Any known or suspected immunodeficient conditions.

13. Past or current history of significant autoimmune diseases, as judged by the
Investigator.

14. Known or suspected infection with human immunodeficiency virus (HIV), hepatitis C
virus (HCV), or hepatitis B virus (HBV) at screening.

15. Current history of medical illness such as diabetes, hypertension, heart, renal or
hepatic diseases, as judged by the Investigator.

16. Hereditary or acquired hemorrhagic tendency or coagulation dysfunction (e.g.,
cytokine defects, coagulation disorders or platelet disorder), or history of serious
bleeding, or history of massive bleeding after intramuscular injection, intravenous
puncture or ecchymosis.

17. History of receiving blood, blood components or immunoglobulins within 3 months
prior to the day of vaccination, or planned to receive such product during the whole
study period.

18. Presence of an acute febrile illness on the day of planned vaccination or within 72
hours prior of it (oral temperature>38.0°C; temporary exclusion criterion).

19. Past or current history of any progressive or severe neurological disorder, seizure
disorder or Guillain-Barré syndrome.

20. Behavioral or cognitive impairment, or psychiatric disease that, in the opinion of
the Investigator, may interfere with the subject's ability to participate in the
study.

21. Past (stopped less than 6 months before enrolment) or current smoking habit above 10
cigarettes per day.

22. Past (stopped less than 6 months before enrolment) or current history of alcohol
consumption (more than 2 glasses per day, more than 10 glasses per week, or absence
of any days within a week without consumption. A standard glass contains 10 g of
alcohol corresponding to 10 cl of wine, 25 cl of beer at 5% or 3 cl of alcohol at
40% [Société Française d'Alcoologie, 2023]).

23. Past (stopped less than 6 months before enrolment) or current history of use of
recreational drugs.

24. Prophylactic or therapeutic use of any anti(retro)virals by systemic route during
the study. Topical application is allowed.

25. History of severe allergic reactions and/or anaphylaxis, or serious adverse
reactions to vaccines or allergy to kanamycin.

26. Any contraindication to intramuscular administration, as judged by the Investigator.

27. Individuals with history of any illness that, in the opinion of the Investigator,
might interfere with the results of the study, or pose additional risk to the
subjects due to participation in the study, either directly or through any
treatments administered for that illness.

28. Sponsor employees or Investigator site personnel directly affiliated with this
study, and their immediate families. Immediate family is defined as a spouse (or
assimilated), parent, child or sibling, whether biological or legally adopted.

29. Subjects receiving ≥10 mg/day of prednisone or equivalent for more than 3 months
before study entry.

30. Health professionals and/or students for whom vaccination against SARS-CoV-2 is
strongly recommended.