Inclusion Criteria:

1. Healthy participants 18-59 years, and both males and females should be included;

2. Participants who agree to participate in this clinical trial voluntarily and sign
the informed consent form, capable of providing valid identification, understanding
and complying with the requirements of the clinical protocol.

3. For female participants of childbearing potential, effective contraception measures
should be used within 2 weeks prior to participation in this study and the results
of the pregnancy test must be negative. Participants must voluntarily agree to use
effective contraceptive measures from the time of signing the informed consent to
the end of the study (effective contraceptive measures including oral contraceptives
(excluding emergency contraceptives), injectable or implantable contraceptives,
sustained-release topical contraceptives, hormonal patches, intrauterine device,
sterilization, abstinence, condoms (for males), diaphragms, cervical caps, etc.).

4. Body mass index within range of 18~30 kg/m2

Exclusion Criteria:

1. Abnormal results of laboratory screening tests (exceeding the upper or lower limit
of the normal reference range by a factor of 1.2) which was clinically significant
judged by clinicians at screening;

2. Abnormal vital signs with clinical significance at screening, with systolic blood
pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, or pulse <50 beats/min or
>100 beats/min under conscious state, or axillary temperature ≥ 37.3°C at screening;

3. Known allergy, or history of anaphylaxis, or other serious adverse reactions to
study vaccine or its excipients;

4. History of human coronavirus infection/diseases, such as severe acute respiratory
syndrome (SARS) or Middle East respiratory syndrome (MERS);

5. History of COVID-19, or history of close contact with confirmed/suspected COVID-19
patients, or positive results for either SARS-CoV-2 nucleic acid or antibody tests
(IgG and IgM) at screening;

6. Administration of antipyretics or painkillers within 24 hours prior to vaccination;

7. Receipt of any COVID-19 vaccine, live attenuated vaccine within 28 days prior to
vaccination, subunit and inactivated vaccine within 14 days prior to vaccination;

8. Blood donation or blood loss (≥450 mL), or receipt of blood or blood-related
products, including immunoglobulins, within 3 months prior to vaccination; or any
planned blood donation or blood products use during the study period.

9. Participants with the following disease:

1. Any acute diseases or acute attacks of chronic diseases within 7 days prior to
vaccination；

2. Congenital malformations or developmental disorders, genetic defects, severe
malnutrition, etc.；

3. Congenital or acquired immunodeficiency or autoimmune disease, or long-term
receipt (>14 consecutive days) of glucocorticoid (reference value for dose: ≥20
mg/day prednisone or equivalent) or other immunosuppressive agents within the
past 6 months, with exception of inhaled or topical steroids, or short-term use
(≤14 consecutive days) of oral corticosteroids；

4. Currently suffering from or previously diagnosed with infectious diseases,
positive screening results for hepatitis B surface antigen, hepatitis C
antibody, treponema pallidum antibody, human immunodeficiency virus antibody；

5. History or family history of neurological disorders (convulsions, epilepsy,
encephalopathy, etc.) or psychiatric disorders；

6. Asplenia, or functional asplenia；

7. Presence of severe, uncontrollable or hospitalization indicated cardiovascular
diseases, diabetes, blood and lymphatic diseases, immune diseases, liver and
kidney diseases, respiratory diseases, metabolic and musculoskeletal diseases,
or malignant tumors, except for history of well-controlled chronic diseases,
such as diabetes, hypertension, etc.;

8. Participants who cannot tolerate venepuncture, or have a history of needle or
blood phobia;

9. Contraindications to IM injections and blood draws, such as coagulation
disorders, thrombotic or bleeding disorders, or conditions that need continuous
anticoagulant usage.

10. Drug or alcohol abuse (alcohol intake ≥ 14 units per week), which in the
investigator's opinion, would compromise the participant's safety or compliance with
the study procedure;

11. History of a major surgery, per the investigator's judgment, within 12 weeks before
enrolment, or not achieving full recovery after surgery, or any planned major
surgery during the study;

12. Pregnant or lactating females; males whose partner plans to conceive; males or
females who plan to donate sperm or eggs;

13. Having participated or being participating in COVID-19 clinical trials, and those
being participating or planning to participate in other clinical trials during the
study period;

14. Receipt of any investigational or unlicensed products (drug, vaccine, biological
product or device) other than the investigational vaccine within 3 months prior to
signing the informed consent form, or plan to use them during the study;

15. Presence of any underlying disease or condition which, in the opinion of the
investigator, may place the participant at unacceptable risk, make the participant
unable to meet the requirements of the protocol, or interfere with the assessment of
vaccine elicited response.