A total of 300 healthy volunteers between the ages of 18 and 80 with no previous historyof COVID-19 will be entered into the study and will receive IPV by injection on Day 1.Blood specimens collected pre-inoculation will be tested for cross-reactivity topoliovirus and SARS-CoV-2 by Western blot. An additional specimen will be collected onDay 28 post-inoculation and, likewise tested for cross-reactivity to poliovirus andSARS-CoV-2.The number of subjects with an immune response to SARS-CoV-2 antigens followinginoculation with IPV will be summarized.
A total of 300 healthy volunteers between the ages of 18 and 80 with no previous history
of COVID-19 will be entered into the study and will receive IPV by injection on Day 1.
Blood specimens collected pre-inoculation will be tested for cross-reactivity to
poliovirus and SARS-CoV-2 by Western blot. An additional specimen will be collected on
Day 28 post-inoculation and, likewise tested for cross-reactivity to poliovirus and
SARS-CoV-2.
If the results from this study demonstrate that polio vaccine induces an immune response
against both the immunogen (poliovirus) and SARS-CoV-2, the study may be amended after
consultation with the Center for Biologics evaluation and research (CBER), to enroll an
additional 275 subjects. Expansion of the original cohort will be stratified by age and
race/ethnicity.
The number of subjects with an immune response to SARS-CoV-2 antigens following
inoculation with IPV will be summarized.
Vaccination for poliomyelitis is part of routine childhood vaccination. Only IPV has been
administered in the United States since the year 2000 as a series of 4 inoculations in
childhood inducing an immunity which, although protective for years, wans over time and
is, for the most part, undetectable in adults unless a booster is administered. United
States residents are advised to receive a booster prior to travelling to countries where
polio disease remains endemic.
Inactivated vaccines against RNA viruses (including Poliovirus and coronavirus) induce an
immune response that recognizes the non-structural antigens of the inactivated viral
particle. There is extensive homology between Poliovirus and SARS-CoV-2
RNA-dependent-RNA-polymerase (RdRp) both within the coding regions and illustrated in the
3-dimensional modeling. The homology between the viral epitopes may be sufficient such
that adults who receive a polio booster develop an immune response that cross-reacts with
SARS-CoV-2. Consequently, the neutralizing activity of antibodies raised to SARS-CoV-2
RdRp will be evaluated.To evaluate and characterize the immune response to SARS-CoV-2
elicited in adults by IPV.
Primary Objective: To evaluate whether an immune response to SARS-CoV-2 RdRp is induced
in adults receiving a booster inoculation of IPV.
Secondary Objectives:: To evaluate the neutralizing activity of antibodies raised to
SARS-CoV-2 RdRp
This is a single-site study in a clinic in San Diego California that routinely diagnoses
and manages patients with COVID-19.
Biological: Vaccinated with polio vaccine (IPV)
poliovirus vaccine (IPV) manufactured by Sanofi Pasteur for distribution in the United
States
Inclusion Criteria:
1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study procedures and availability for the
duration of the study
3. Male or female, aged 18-80
4. Female subjects of child-bearing potential must have a negative pregnancy test
(point-of-care dipstick) prior to being vaccinated and be willing to use an
effective method of birth control from the time of entry into the study and for 30
days following vaccination
5. In good general health with no active infectious disease as evidenced by medical
history and directed physical examination.
Exclusion Criteria:
1. Known allergic reactions to components of the polio vaccine
2. Febrile illness within 14 days
3. Positive for SARS-CoV-2 antigenemia at any time prior to screening1
4. Positive for SARS-CoV-2 antibodies at any time prior to screening1
5. Subjects with fever > 101o F at screening
6. Subjects who respond yes to any of the following question:
Have you experienced any of the following symptoms in the past 48 hours (14):
- fever or chills
- cough
- shortness of breath or difficulty breathing
- fatigue
- muscle or body aches
- headache
- new loss of taste or smell
- sore throat
- congestion or runny nose
- nausea or vomiting
- diarrhea
7. Treatment with an investigational drug or other intervention within the 90 days
prior to enrollment in this study
8. Inoculation with polio vaccine within the last 12 years
9. Women who are pregnant or breast feeding
Rac Ii Md
National City, California, United States
John Andrews, Study Chair
E-MO Biology Inc