Official Title
Methodological Design for Evaluating the Immune Capacity of Bivalve Fluids From Anodonta Cygnea in SARS and COVID-19 Human Infection: Intelligent Medicine Integration.
Brief Summary

The present work proposes to find if a bio-active composite in the hemolymph or plasma ofthe freshwater bivalve Anodonta cygnea is able to offer immunity and specificity formeliorating the major symptoms in human SARS and COVID-19 lineage infection. TheMethodology concerns in silico procedures using organic fluids from 54 bivalves (in veryspecific conditions) to evaluate their therapeutic effects in 6 voluntary SARS andCOVID-19 infected persons with an integrative diagnosis by a computational Mora®Novaapparatus to access the basal and experimental human physiological parameters.

Detailed Description

A deep and consistent study will be developed with an increase in the human sampling for
better understanding the intervention efficacy of this intelligence medicine integrator,
the Mora® Nova method. These in silico experiments when associated with the bioresonance
frequencies from stimulated hemolymph compounds of the freshwater bivalve A. cygnea, may
lead us to expect high plasticity and immunological potential.

Obviously, additional in vitro studies in future, with adequate culture cell lineages in
different conditions and with bioresonance treatment by Mora® Nova method, should also be
accomplished with hemolymph/plasma interference to confirm the pertinence, and the real
efficacy on SARS / COVID-19 infection as well as to clarify the respective biological
mechanisms.

In addition, to analyze and evaluate any specific bioactive compound from the induced
hemolymph condition needs molecular experiments which can give deep structural
information concerning any efficient molecule against the SARS / COVID-19 virus lineage
and respective mutants. Effectively, according to current scientific opinion, the virus
mutation phenomenon leads to great and problematic difficulty for maintaining the
collective and human global immunization. In this case, the present Mora methodology
offers a very functional, dynamic, and efficient process when combined with a biological
model, as the bivalve A. cygnea, with high plasticity and eventual molecular
reconstructive adaptation. This Mora procedure can extend to other immune-depressive
diseases namely cancer, rheumatoid arthritis, and neurodegenerative diseases combining
with respective stimulated bivalve fluids. It suggests opening a promising future
perspective when applied to large human sampling as well as with in vitro cellular
assays.

In addition, to explore this research with in vitro cell cultures and to do the
characterization and the effects from bio-compounds on similar diseases is our close
objective.

Unknown status
Coronavirus Infections
Coronavirus Sars-Associated
SARS (Severe Acute Respiratory Syndrome)
COVID-19

Biological: Marine liquid and fluids

Marine liquid and fluids extracted from freshwater bivalve of A. cygnea (under very
specific conditions)

Biological: Impregnation

SARS / COVID-19 fluid/liquid - impregnation

Biological: Incubation

SARS / COVID-19 fluid-bivalve-incubation

Biological: Manipulation

Bivalve Manipulation - Stress inducing

Biological: Refrigeration

Refrigerated fluid to check for maintained response

Eligibility Criteria

Inclusion Criteria:

- Subjects with normal physiological state or any kind of comorbidity

Exclusion Criteria:

- Subjects in highly critical health state

Eligibility Gender
All
Eligibility Age
Minimum: 14 Years ~ Maximum: N/A
Countries
Portugal
Locations

Instituto Politécnico de Bragança
Bragança, Portugal

ICBAS - University of Porto
Porto, Portugal

Jorge P Machado, PhD, Study Director
ICBAS - Instituto de Ciências Biomédicas Abel Salazar

Instituto Politécnico de Bragança
NCT Number
MeSH Terms
Infections
COVID-19
Coronavirus Infections
Severe Acute Respiratory Syndrome