The present work proposes to find if a bio-active composite in the hemolymph or plasma ofthe freshwater bivalve Anodonta cygnea is able to offer immunity and specificity formeliorating the major symptoms in human SARS and COVID-19 lineage infection. TheMethodology concerns in silico procedures using organic fluids from 54 bivalves (in veryspecific conditions) to evaluate their therapeutic effects in 6 voluntary SARS andCOVID-19 infected persons with an integrative diagnosis by a computational Mora®Novaapparatus to access the basal and experimental human physiological parameters.
A deep and consistent study will be developed with an increase in the human sampling for
better understanding the intervention efficacy of this intelligence medicine integrator,
the Mora® Nova method. These in silico experiments when associated with the bioresonance
frequencies from stimulated hemolymph compounds of the freshwater bivalve A. cygnea, may
lead us to expect high plasticity and immunological potential.
Obviously, additional in vitro studies in future, with adequate culture cell lineages in
different conditions and with bioresonance treatment by Mora® Nova method, should also be
accomplished with hemolymph/plasma interference to confirm the pertinence, and the real
efficacy on SARS / COVID-19 infection as well as to clarify the respective biological
mechanisms.
In addition, to analyze and evaluate any specific bioactive compound from the induced
hemolymph condition needs molecular experiments which can give deep structural
information concerning any efficient molecule against the SARS / COVID-19 virus lineage
and respective mutants. Effectively, according to current scientific opinion, the virus
mutation phenomenon leads to great and problematic difficulty for maintaining the
collective and human global immunization. In this case, the present Mora methodology
offers a very functional, dynamic, and efficient process when combined with a biological
model, as the bivalve A. cygnea, with high plasticity and eventual molecular
reconstructive adaptation. This Mora procedure can extend to other immune-depressive
diseases namely cancer, rheumatoid arthritis, and neurodegenerative diseases combining
with respective stimulated bivalve fluids. It suggests opening a promising future
perspective when applied to large human sampling as well as with in vitro cellular
assays.
In addition, to explore this research with in vitro cell cultures and to do the
characterization and the effects from bio-compounds on similar diseases is our close
objective.
Biological: Marine liquid and fluids
Marine liquid and fluids extracted from freshwater bivalve of A. cygnea (under very
specific conditions)
Biological: Impregnation
SARS / COVID-19 fluid/liquid - impregnation
Biological: Incubation
SARS / COVID-19 fluid-bivalve-incubation
Biological: Manipulation
Bivalve Manipulation - Stress inducing
Biological: Refrigeration
Refrigerated fluid to check for maintained response
Inclusion Criteria:
- Subjects with normal physiological state or any kind of comorbidity
Exclusion Criteria:
- Subjects in highly critical health state
Instituto Politécnico de Bragança
Bragança, Portugal
ICBAS - University of Porto
Porto, Portugal
Jorge P Machado, PhD, Study Director
ICBAS - Instituto de Ciências Biomédicas Abel Salazar