The purpose of this study is to learn about the effects of the study medicine (calledPaxlovid) for the possible treatment of COVID-19 in older adults who live in long-termcare hospitals (LTCHs) in Korea. Researchers want to know whether Paxlovid lowers thechance of severe illness or death and helps people carry out their usual dailyactivities, remain free from aging and weakness, and maintain cognitive function.This study is seeking participants who: - are 60 years of age or older - live in a long-term care hospital in Korea - were diagnosed with COVID-19 on or after 14 January 2022, during the period when Paxlovid was available as part of routine care - received Paxlovid within 5 days after their first COVID-19 symptoms (only for people in the Paxlovid group)All participants in this study received their usual COVID-19 care. About half alsoreceived Paxlovid. Paxlovid was prescribed as part of routine care at the long-term carehospital, typically taken by mouth 2 times a day for 5 days.The study team will compare the health results of people who received Paxlovid to thosewho did not, using similar parameters such as age, sex, and medical history. This willhelp the study team to understand whether Paxlovid makes a meaningful difference instopping severe illness, death, or slow-down daily functioning.Participants will not have any extra study visits or tests. The study team will onlyreview information already recorded in their medical charts for up to 1 year after theirCOVID-19 symptom onset.
Not Provided
Drug: Nirmatrelvir/Ritonavir
Participants aged 60 years or older residing in long-term care hospitals (LTCHs) in Korea
who were diagnosed with COVID-19 and received Paxlovid (Nirmatrelvir/Ritonavir) as part
of their clinical care. This group will be assessed for multiple outcomes including
mortality, progression to severe disease, worsening of activities of daily living (ADL),
and frailty.
Other Name: Paxlovid
1. LTCH residents ≥60 years of age, diagnosed with COVID-19 via SARS-CoV-2 PCR or
antigen test, with a symptom onset date (index date) between 14 January 2022 and 1
June 2023 (or latest date available)
2. Dispensed Paxlovid within 5 days of COVID-19 symptom onset (Paxlovid treated
patients only)
Not Provided
Pfizer CT.gov Call Center
1-800-718-1021
ClinicalTrials.gov_Inquiries@pfizer.com
Pfizer CT.gov Call Center, Study Director
Pfizer