Inclusion Criteria:

Participant Inclusion Criteria for CST Infusion:

We will enroll participants who are ≥28 days and <4 months post allogeneic HSCT and are
at risk of developing SARS-CoV-2 infection.

1. For receipt of CSTs derived from an HSCT donor under Arm A:

a. Patients aged ≥18 years and <80 years who were recipients of prior myeloablative
or non-myeloablative allogeneic HSCT using either bone marrow or peripheral blood
stem cells or single or double cord blood ≥28 days and <4 months ago who are at risk
of SARS-CoV-2 infection..

2. For receipt of CSTs derived from an HSCT donor under Arm B:

a. Patients aged ≥12 years and <18 years who were recipients of prior myeloablative
or non-myeloablative allogeneic HSCT using either bone marrow or peripheral blood
stem cells or single or double cord blood ≥28 days and <4 months ago who are at risk
of SARS-CoV-2 infection.

3. Have evidence of primary engraftment following HSCT (defined by ANC ≥500/mm3 for
three consecutive measurements on different days, respectively)

4. Participants receiving steroids for treatment of GVHD or for other reasons, dosage
must have been tapered to <0.5 mg/kg/day of prednisone (or equivalent) at least 7
days prior to infusion.

5. Karnofsky/Lansky score >70.

6. ≥12 years to <80 years of age at enrollment.

7. Absolute neutrophil count (ANC) ≥500/ul.

8. Hemoglobin ≥8.0g/dl (level can be achieved with transfusion).

9. Platelets ≥20 K/ul (level can be achieved with transfusion) *.

10. Bilirubin ≤2x upper limit normal.

11. Aspartate transaminase (AST) ≤2.5x upper limit of normal.

12. Alanine transaminase (ALT) ≤2.5x upper limit of normal.

13. Cystatin C with estimated GFR >60mL/min/1.73m2 (calculated via the CKD-EPI 2012
equation).

14. Pulse oximetry of ≥92% on room air for at least 7 days prior to infusion.

15. Age appropriate mean arterial pressure without the use of vasopressors.

16. Negative pregnancy test in female participant of childbearing age.

17. Male and female participants of childbearing age must use highly effective birth
control measures or practice abstinence for a minimum of 6 months after receiving
study therapy.

18. Written informed consent and/or signed assent line from participant, parent or
guardian.

Donor Inclusion Criteria:

1. Donors for allogeneic (i.e. HLA matched or mismatched related or unrelated) stem
cell transplants who have fulfilled eligibility as per FDA regulations outlined in
21 CFR 1271 subpart C. This includes that donors have been deemed in good health by
donor physician based on physical examination and laboratory testing. If a donor has
been chosen for the transplant based on urgent medical need that same donor will
also be used for CST generation provided that there are no new reasons for
ineligibility since the stem cell collection.

2. Donor or guardian of pediatric donor capable of providing informed consent.

3. 2 to 80 years of age.

4. Female donors of childbearing age must have a negative pregnancy test and not be
lactating.

Exclusion Criteria:

Participants Exclusion Criteria for CST Infusion:

1. Participants receiving biological or immunosuppressive monoclonal antibodies
targeting T cells within 28 days prior to CST infusion, including ATG, Alemtuzumab,
Basiliximab, Tociluzimab, Brentuximab, or other medications under this category as
determined by the investigators.

a. If alemtuzumab has been received within 6 weeks prior to CST infusion, plasma
levels should be obtained to ensure drug clearance (≤0.16 pg/ml).

2. Participants who have received donor lymphocyte infusion (DLI), chimeric antigen
receptor T cell infusion, or other experimental cellular therapies within 28 days
prior to CST infusion.

3. Participants who have received ruxolitinib or other JAK inhibitors within 7 days
prior to CST infusion.

4. Participants with uncontrolled or progressing infections or active infections
causing fever (temperature ≥38.1°C). Uncontrolled infections are defined as
bacterial, fungal, or viral infections (including HIV and Hep B and C) with either
clinical signs of worsening despite standard therapy that may be attributed to the
uncontrolled infection. Progressing infection is defined as hemodynamic instability,
worsening physical signs, or radiographic findings attributable to infection.

1. For bacterial infections, participants must be receiving definitive therapy and
have no signs of progressing infection within 7 days prior to CST infusion.

2. For fungal infections, participants must be receiving definitive systemic
anti-fungal therapy and have no signs of progressing infection within 7 days
prior to CST infusion.

5. Participants with unexplained fever (temperature ≥38.1°C) within 7 days prior to CST
infusion.

6. Participants with evidence of active SARS-CoV-2 infection based on SARS-CoV-2 RT-PCR
positivity.

7. Participants with fever (temperature ≥38.1°C) in the past 7 days.

8. Participants with hypotension (systolic blood pressure <90 mmHg or mean arterial
blood pressure <55 mmHg in participants <14 years of age or <60 mmHg in participants
≥14 years of age).

9. Participants with pulse pressure >40 mmHg.

10. Participants with respiratory rate >20 breaths per minute.

11. Participants with heart rate ≥120 beats per minute.

12. Participants with uncontrolled hypertension as defined by systolic blood pressure
>99th percentile for age (children <18 years), and systolic blood pressure ≥130 mmHg
or diastolic blood pressure ≥80 mmHg (participants ≥18 years).

13. Participants with metabolic instability.

14. Pediatric participants with modified Ross heart failure Class II disease and adult
participants with NYHA Class II disease.

15. Participants with advanced pulmonary disease as defined by requirement for
supplemental oxygen or positive pressure ventilation due to pulmonary disease. (This
includes participants with active interstitial lung disease (ILD)/pneumonitis,
advanced pulmonary disease, a history of ILD/pneumonitis requiring treatment with
systemic steroids or a baseline oxygen requirement).

16. Participants with neurological or psychiatric disorders that would, in the opinion
of the investigators, place them at increased risk of harm, impact the
investigator's abilities to screen for adverse events in the subject, or impair the
subject's ability to provide informed consent.

17. Participants receiving checkpoint inhibitors within the previous 3 months prior to
CST infusion, including nivolumimab, pembroluzimab, or other related medications.

18. Participants with proven or suspected MIS (in both adults and children) based on the
CDC definition and investigator judgement.

19. Participants who are breastfeeding.

20. Participants who have received live vaccines within 30 days, or any SARS-CoV-2
vaccine in the past 28 days prior to enrollment.

21. Participants with any other unrelated medical conditions that would impact the
participant's safety in the opinions of the investigators.

22. Participants anticipated to need a blood transfusion within 48 hours of CST
infusion.

23. Participants unwilling to utilize effective contraception during the study period
(if applicable)

Donor Exclusion Criteria:

1. Donation of cells would pose a physical or psychological risk to the donor.

2. Prior or current complicated course of COVID-19, including but not limited to MIS,
CRS, or thromboembolic complications based on investigator judgement.