Inclusion Criteria:

1. Age 18 years and over at the time of screening.

2. Body weight over 30 kg.

3. Confirmed HCC based on histopathological findings from tumour tissues.

4. Must not have received prior systemic therapy for HCC.

5. Must not be eligible for locoregional therapy for resectable HCC. For patients who
progressed after locoregional therapy for HCC, locoregional therapy must have been
completed at least 28 days before the baseline scan for the programme.

6. Barcelona Clinic Liver Cancer (BCLC) stage B (that is not eligible for locoregional
therapy) or stage C (refer to Appendix H).

7. Child-Pugh Score Class A; or Child-Pugh Class B7 or B8 at discretion of treating
physician (refer to Appendix I).

8. Patients with HBV infection, characterised by positive hepatitis B surface antigen
(HBsAg) and/or hepatitis B core antibodies (anti-HBcAb) with detectable HBV
deoxyribonucleic acid (DNA) (≥10 IU/mL or above the limit of detection per local or
central lab standard), must be treated with antiviral therapy, as per institutional
practice to ensure adequate viral suppression (HBV DNA <2000 IU/mL) before
enrolment. Patients must remain on antiviral therapy for the duration of their
participation in the EAP and for 6 months after the last dose of EAP medication.
Patients who test positive for anti-hepatitis B core (HBc) with undetectable HBV DNA
(<10 IU/mL or under the limit of detection per local or central lab standard) do not
require anti-viral therapy before enrolment. These participants will be tested at
every cycle to monitor HBV DNA levels and initiate anti-viral therapy if HBV DNA is
detected (≥10 IU/mL or above the limit of detection per local or central lab
standard). HBV DNA detectable patients must initiate and remain on anti-viral
therapy for time they are in the EAP and for 6 months after the last dose of EAP
medication.

9. Patients with HCV infection must have confirmed diagnosis of HCV characterised by
the presence of detectable HCV ribonucleic acid (RNA) or anti-HCV antibody upon
enrolment (management of this disease is per local institutional practice).

10. At least 1 measurable lesion, not previously irradiated, that can be accurately
measured at baseline ≥10 mm in the longest diameter (except lymph nodes, which must
have as short axis ≥15 mm) with computerised tomography (CT) or magnetic resonance
imaging (MRI), and that is suitable for accurate repeated measurements as per RECIST
1.1 guidelines (Eisenhauer et al, 2009). A lesion which progressed after previous
ablation or transarterial chemoembolization (TACE) could be measurable if it meets
these criteria.

11. Adequate organ and marrow function, as defined below. Criteria "a", "b", "c", and
"f" cannot be met with transfusions, infusions, or growth factor support
administered within 14 days of starting the first dose of EAP treatment.

1. Haemoglobin ≥9 g/dL

2. Absolute neutrophil count ≥1000/μL

3. Platelet count ≥75,000/μL

4. Total bilirubin (TBL) ≤2.0 x upper limit of normal (ULN)

5. AST and ALT ≤5xULN

6. Albumin ≥2.8 g/dL

7. International normalised ratio (INR) ≤1.6. Note: INR prolongation due to
anticoagulants for prophylaxis (e.g., atrial fibrillation) in patients without
liver cirrhosis could be exception.

8. Calculated creatinine clearance ≥50 mL/minute as determined by Cockcroft Gault
(using actual body weight) or 24-hour urine creatinine clearance

12. Evidence of post-menopausal status or negative urinary or serum pregnancy test for
female pre-menopausal patients. Women will be considered post-menopausal as
described in Section 5.3.4.

13. Must have a life expectancy of at least 12 weeks.

14. Willing and able to comply with the protocol for the duration of the EAP including
undergoing treatment and scheduled visits and examination including follow up.

15. Able to provide written informed consent and any locally-required authorisation
(e.g., Health Insurance Portability and Accountability Act [HIPAA] in the United
States [US], European Union [EU] Data Privacy Directive in the EU) obtained from the
patient/legal representative before performing any protocol-related procedures,
including screening evaluations.

Exclusion Criteria:

Patients should not enter the EAP if any of the following exclusion criteria are
fulfilled:

1. Concurrent enrolment in a clinical study unless it is an observational (non
interventional) clinical study or during the follow-up period of an interventional
study.

2. Have received an investigational product within 28 days before the first dose of EAP
treatment.

3. Any unresolved toxicity National Cancer Institute (NCI) Common Terminology Criteria
for Adverse Event (CTCAE) Grade ≥2 from previous anticancer therapy except alopecia,
vitiligo, and the laboratory values defined in the inclusion criteria:

- Patients with Grade ≥2 neuropathy will be evaluated on a case-by-case basis
after consultation with the Treating Physician.

- Patients with irreversible toxicity not reasonably expected to be exacerbated
by treatment with durvalumab or tremelimumab may be included only after
consultation with the Treating Physician.

4. Any concurrent chemotherapy, study drug, or biologic or hormonal therapy for cancer
treatment. Concurrent use of hormonal therapy for non-cancer-related conditions
(e.g., hormone replacement therapy) is acceptable.

5. Known allergy or hypersensitivity to any of the EAP treatments or any of the EAP
treatment excipients.

6. Child-Pugh Score Class B9; or Child-Pugh Class C

7. Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of
radiation within 28 days of the first dose of EAP treatments.

8. Major surgical procedure (as defined by the Treating Physician) within 28 days
before the first dose of EAP treatment. Note: local surgery of isolated lesions for
palliative intent is acceptable.

9. History of allogenic organ transplantation (e.g., liver transplant).

10. History of hepatic encephalopathy within the past 12 months or requirement for
medications to prevent or control encephalopathy (e.g., no lactulose, rifaximin, etc
if used for purposes of hepatic encephalopathy.

11. Clinically meaningful ascites, defined as any ascites requiring non-pharmacologic
intervention (e.g., paracentesis) to maintain symptomatic control, within 6 months
before the first EAP treatment dose. Patients on stable doses of diuretics for
ascites for ≥2 months are eligible.

12. Patients with main portal vein thrombosis (i.e., thrombosis in the main trunk of the
portal vein, with or without blood flow) on baseline imaging.

13. Active or previously documented GI bleeding (e.g., oesophageal varices or ulcer
bleeding) within 12 months. (Note: for patients with history of GI bleeding for >12
months or assessed as high risk for oesophageal variceal by the Treating Physician,
adequate endoscopic therapy according to institutional standards is required).

14. Patient currently exhibits symptomatic or uncontrolled hypertension defined as
diastolic blood pressure >90 mmHg or systolic blood pressure >140 mmHg.

15. Any condition interfering with swallowing pills, or other contraindication to oral
therapy, or uncontrolled diarrhoea.

16. Active or previously documented autoimmune or inflammatory disorders (including
inflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis
[except for diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome, or
Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid
arthritis, hypophysitis, uveitis, etc]). Patients without active disease in the last
5 years are excluded unless discussed with the Treating Physician and considered
appropriate for EAP participation. The following are exception to this criterion:

- Patients with vitiligo or alopecia

- Patients with hypothyroidism (e.g., following Hashimoto syndrome) stable on
hormone replacement

- Any chronic skin condition that does not require systemic therapy

- Patients with celiac disease controlled by diet alone

17. Patients co-infected with HBV and HCV, or co-infected with HBV and hepatitis D virus
(HDV). HBV positive (presence of HbsAg and/or anti-HBcAb with detectable HBV DNA);
HCV positive (presence of anti-HCV antibodies); HDV positive (presence of anti-HDV
antibodies).

18. Uncontrolled intercurrent illness, including but not limited to, ongoing or active
infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable
angina pectoris, cardiac arrhythmia, interstitial lung disease (ILD), serious
chronic GI conditions associated with diarrhoea, inferior vena cava thrombosis, or
psychiatric illness/social situations that would limit compliance with EAP
requirement, substantially increase the risk of incurring AEs, or compromise the
ability of the patient to give written informed consent.

19. History of another primary malignancy except for:

- Malignancy treated with curative intent and with known active disease ≥5 years
before the first dose of EAP treatment and of low potential risk for recurrence

- Patients with a history of prostate cancer of stage biochemical recurrence or progression and who, in the opinion of the Treating
Physician are not deemed to require active intervention

- Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
of disease

- Adequately treated carcinoma in situ without evidence of disease

20. History of leptomeningeal carcinomatosis.

21. History of, or current, brain metastases or spinal cord compression. Patients with
suspected brain metastases at screening should have an MRI (preferred) or CT, each
preferably with IV contrast of the brain before EAP entry.

22. Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC.

23. History of active primary immunodeficiency.

24. Active infection including tuberculosis (TB) (clinical evaluation that includes
clinical history, physical examination and radiographic findings, and TB testing in
line with local practice), or human immunodeficiency virus (HIV; positive HIV 1/2
antibodies).

25. Current or prior use of immunosuppressive medication within 14 days before the first
dose of EAP treatment. The following are exceptions to this criterion:

- Intranasal, inhaled, topical steroids, or local steroid injections (e.g.,
intra-articular injection)

- Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of
prednisone or its equivalent

- Steroids as pre-medication for hypersensitivity reactions (e.g., CT scan
pre-medication)

26. Receipt of live attenuated vaccine within 30 days before the first dose of EAP
treatment. Note: patients, if enrolled, should not receive live vaccine while
receiving EAP treatments, and up to 30 days after the last dose of EAP treatment.

27. Female patients who are pregnant or breastfeeding, or male or female patients of
reproductive potential who are not willing to employ effective birth control from
screening to 180 days after the last dose of durvalumab+tremelimumab or 90 days
after the last dose of durvalumab monotherapy. Not engaging in sexual activity, as
per the patient's preferred and usual lifestyle, for the total duration of the
treatment and washout periods is an acceptable practice.

28. Previous randomisation or treatment in a previous durvalumab and/or tremelimumab
clinical study regardless of treatment arm assignment.

29. Patients who have received anti-PD-1, anti-PD-L1, or anti-CTLA-4 before the first
dose of EAP treatment.

30. Patient has any condition that, in the opinion of the Treating Physician would
interfere with the evaluation of the programme drug or interpretation of patient
safety