CVS Health is one of the nation's leading healthcare benefits companies. CVS Health became an FDA Sentinel Data Partner in 2010 and provides access to approximately 23 million people (both current and former enrollees) for public health research. CVS Health’s IMEDS population has national representation, including individuals who live in every state and Washington DC, and territories including American Samoa, Guam, U.S. military bases outside of U.S., Marshal Islands, Northern Mariana Islands, Palau, and Puerto Rico.

Harvard Pilgrim Health Care is one of the country's premier health plans. It is a large non-profit health plan with diverse enrollees across Massachusetts, Maine, and New Hampshire. Approximately 3.8 million researchable lives (both current and former enrollees) are available for study by Harvard Pilgrim Health Care Institute (HPHCI), a research and academic partnership between Harvard Medical School and Harvard Pilgrim Health Care. HPHCI also participates in the IMEDS program as the IMEDS Analytic Center.

HealthCore, Inc., a wholly-owned subsidiary of Anthem, Inc., uses real-world data to conduct outcomes, health economics, pharmacoepidemiologic, and late phase research. The HealthCore Integrated Research Database is a proprietary, fully integrated, longitudinal claims database that combines medical, pharmacy, and laboratory information drawn from 66 million unique individuals with medical coverage and historically more than 48.8 million researchable lives with medical and pharmacy claims information through 2006. HealthCore and Anthem have coverage across all 50 states, including 14 ‘Blue’ states (California, Colorado, Connecticut, Georgia, Indiana, Kentucky, Maine, Missouri, Nevada, New Hampshire, New York, Ohio, Virginia, and Wisconsin) covered by Blue Cross or Blue Cross Blue Shield licensed commercial plans.

HealthPartners Institute is a 501(c)(3) nonprofit organization dedicated to conducting high-quality, public-domain health research, often in collaboration with other academic and research organizations throughout the world. Health Partners employs 33 career research investigators and more than 400 clinician researchers and encompasses vast and varied areas of research. HealthPartners includes claims and integrated health system data on more than 3.35 million people (both current and former enrollees) across Minnesota, Wisconsin and Iowa – with the highest density in the twin cities metropolitan area and its adjacent Wisconsin suburb.

Humana/Humana Healthcare Research is a health economics and outcomes research subsidiary of Humana, which focuses on treatment effectiveness, drug safety, adherence, medical and pharmacy benefit design, disease management programs, and other healthcare services. Humana/Humana Healthcare Research has been an active collaborator and Data Partner in the FDA Sentinel System, the Patient-Centered Outcomes Research Institute's National Patient-Centered Research Network, and several Distributed Research Network initiatives. More than 27 million researchable lives are available for research within this health system since 2007. Humana’s geographic coverage for the IMEDS research population includes every U.S. state and is predominantly a Medicare population.

Kaiser Permanente Washington Health Research Institute (KPWHRI) has been a Sentinel Partner since its inception and has recently joined the IMEDS Network. KPWHRI is led by a faculty of investigators, research associates, and biostatisticians. Faculty members have graduate training and experience in medicine, psychology, epidemiology, biostatistics, economics, anthropology, and other relevant disciplines. Nationally recognized for rigorous and innovative methods, researchers typically work in interdisciplinary teams, bringing new perspectives to challenging questions. Most KPWHRI faculty members have secondary appointments at the University of Washington, Fred Hutchinson Cancer Research Center, or other academic institutions, contributing to teaching and research there. They also help train tomorrow’s scientific leaders, including postdoctoral fellows and UW students.Kaiser Permanente Washington’s population includes 700,000 researchable lives throughout Northwest Washington, Central Washington, Eastern Washington, the Coastal and Olympic region, and Puget Sound in any given year. As an integrated system, electronic health record and claims data for its entire population is available for public health research. In 2017, Kaiser Permanente acquired Group Health Cooperative and its subsidiaries as Kaiser Permanente Washington, which have been caring for members in Washington since 1947.

Marshfield Clinic Health System is an integrated system serving mostly rural central, northern, and northwestern Wisconsin with more than 10,000 employees and more than 1,200 providers comprising 86 medical specialties and sub-specialties, a health plan, and longstanding research and education programs. The Clinic has approximately 3.5 million patient encounters each year at more than 50 clinics and 7 hospitals. Data from approximately 390,000 unique patients (past and present) since 2000 who are insured by the Security Health Plan and seek care in the Marshfield Clinic Health System are available for research.

Meyers Primary Care Institute was established in 1996, as a joint endeavor of the University of Massachusetts Medical School, Reliant Medical Group (previously Fallon Clinic), and Fallon Health. The Institute is committed to research across the lifespan, from childhood to advanced age and conducts population-based research to inform policy and practice, promoting evidence-based care for the benefit of our community, and beyond. As a Network Partner, Meyers has access to claims data from 207,000 current members of Fallon Health (annual member enrollment; approximately 807,000 unique patients historically) and linked electronic health record data for 50% of members who are cared for at Reliant Medical Group practices. The geographic coverage for the population that is included for IMEDS research includes Massachusetts, Connecticut, Rhode Island, and New Hampshire. 

Vanderbilt University Medical Center is a comprehensive health care facility dedicated to patient care, research, and the education of health care professionals. Its reputation for excellence in each of these areas has made Vanderbilt a major patient referral center for the South, Southeast and Midwest. The geographic coverage for the population that is included for IMEDS research includes the state of Tennessee through Tennessee Medicaid (TennCare). TennCare insures approximately 1.4 million Tennesseans annually, with an over-representation of women of child-bearing age and children. Fifty percent of women giving birth in Tennessee are insured by TennCare at the time of birth. VUMC has a long history of using these data for pharmacoepidemiologic research, with review and approval by the Division of TennCare. TennCare data is used for Sentinel and IMEDS analyses and includes more than 3.4 million past and present researchable lives (900,000 current).