Inclusion Criteria:

Patients eligible for inclusion in this Treatment Plan have to meet all of the following
criteria:

1. Has or is willing to give consent to the Treating Physician in accordance with the
local regulatory requirements, with age at the time of consent ≥18 years.

2. Has confirmed BRAF V600 or other BRAF activating mutation-positive metastatic
melanoma. Histologically Stage IIIC (unresectable) or Stage IV (metastatic)
cutaneous melanoma with confirmed BRAF V600E/K positive mutation.

3. All clinical trials that the patient might qualify for have been ruled out.

4. Is receiving care at a clinical site with a Treating Physician who has experience
with administering investigational agents for the end-stage melanoma population, or
the patient is willing and/or able to travel to a site and receive treatment under
the guidance of physician with this experience. NOTE: The latter option would
require the patient being evaluated in advance by the Treating Physician at the
experienced site and his/her agreement to assume responsibility for the care of the
patient.

5. Is able to retain oral medication and swallow tablets/capsules (appropriate
exceptions allowed for patients who are unable to swallow tablets/capsules - this is
subject to availability of alternative (liquid) oral formulations).

6. Does not require treatment with any (other) anti-cancer medication (exceptions might
be allowed and are subject to individual evaluation).

7. For patients with active brain metastases: the patient does not require or is
ineligible for immediate local treatment.

8. Is not eligible for participation in any of the IMP's ongoing clinical trials or has
recently completed a clinical trial that has been terminated and, after considering
other options (e.g., trial extensions, amendments, etc.), the clinical team has
determined that treatment is necessary and there are no other feasible alternatives
for the patient.

9. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 3 (or
equivalent) and is in stable clinical condition. NOTE: patient in rapidly
deteriorating clinical condition prior to start of therapy should not be considered
for this program.

10. Does not require treatment with prohibited concomitant medications

11. Women of childbearing potential must have a negative serum beta-human chorionic
gonadotropin (HCG) pregnancy test performed within 14 days prior to starting
dabrafenib and trametinib treatment. Subjects with a positive pregnancy test result
must be excluded from the program. Subjects with a negative pregnancy test result
must agree to use an effective contraception method as described below throughout
the treatment period and for a total of 4 months following the last dose of
treatment.

Contraceptive Methods for Females of Childbearing Potential:

- An intrauterine device with a documented failure rate of less than 1% per year

- Vasectomized partner who is sterile prior to the female patient's entry into the
Compassionate Use program, and this male is the sole sexual partner for that female.

- Complete abstinence from sexual intercourse for 14 days prior to first dose of
treatment, through the dosing period, and for at least 4 months after the last dose
of treatment. Abstinence is only acceptable when in line with the preferred and
usual lifestyle of the subject. Periodic abstinence (e.g. calendar, ovulation,
symptothermal, post-ovulation methods, etc.) and withdrawal are not acceptable
methods of contraception.

- Double-barrier contraception: condom and occlusive cap (diaphragm or cervical/vault
caps) with vaginal spermicidal agent (foam/gel/cream/suppository).

Note: Hormonal-based methods (e.g., oral contraceptives) are not permitted as
contraception due to potential drug-drug interactions with dabrafenib.

Females Not of Childbearing Potential Non-childbearing potential (i.e., physiologically
incapable of becoming pregnant) is defined as any female who has had a documented
hysterectomy, bilateral oophorectomy (ovariectomy), bilateral tubal ligation or tubal
occlusion, or is post-menopausal.

A practical definition accepts menopause after 1 year without menses with an appropriate
clinical profile; e.g., age appropriate, >45 years in the absence of hormone replacement
therapy (HRT). In questionable cases, the patient must have a follicle stimulating
hormone (FSH) value >40 mIU/mL and an estradiol value <40 pg/mL (<140 pmol/L).

Female patients determined not to be post-menopausal must use adequate contraception, as
defined immediately above for females of childbearing potential.

Female subjects who are lactating must discontinue nursing prior to the first dose of
program treatment and must refrain from nursing throughout the treatment period and for 4
months following the last dose of program treatment.

If a subject becomes pregnant during the treatment period of the program, the treatments
should be stopped immediately.

Written patient informed consent must be obtained by the Treating Physician prior to
start of treatment in accordance with the applicable local regulatory requirements.

Exclusion Criteria:

Patients eligible for this Treatment Plan must not meet any of the following criteria:

1. Uveal or mucosal melanoma.

2. Female who is pregnant or nursing (patient must discontinue nursing in order to
enroll in the program).

NOTE: Safety and efficacy in pregnant or nursing women has not been investigated.
Inclusion of pregnant or nursing woman may be considered in individually upon review
by the Novartis Country Pharma Organization Medical Advisor/Director.

3. Patients who have any lab abnormalities or AE/SAEs greater than Grade 3 (CTCAE v5.0)

4. Concurrent treatment with other systemic anti-cancer therapies is not allowed, with
the exception of whole brain radiation and brain radiosurgery. Patients who are
currently being treated with another systemic anti-cancer therapy (e.g.,
chemotherapy, immune, biologic, or targeted therapy) must discontinue use prior to
initiation of treatment with trametinib and dabrafenib. NOTE: Radiation skin injury
has been reported with concurrent use of dabrafenib and radiation. All AEs/SAEs
related to WBRT (whole brain radiation) or brain radiosurgery are required to
resolve to Grade 1 or less (CTCAE v5.0) prior to start of the Managed Access Program
treatment.

5. Patients who have received prior therapy with a BRAF inhibitor other than
dabrafenib.

NOTE: Consideration may be given to those patients who have either (1) received
prior BRAF therapy and there is disease progression in the CNS only or (2)
discontinued prior BRAF therapy due to an adverse event that is not likely to recur
in response to treatment with Dabrafenib

6. Presence of any malignancy with confirmed activating RAS mutation. NOTE: Prospective
RAS testing is not required. However, if the results of previous RAS testing are
known, they must be used in assessing eligibility.

7. Has a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs
chemically related to trametinib or dabrafenib, or excipients or to dimethyl
sulfoxide (DMSO).

8. Any medical conditions or physical examination or clinical laboratory findings which
would put the patient at high risk for an adverse outcome.

9. Current evidence / risk of retinal vein occlusion (RVO) or central serous
retinopathy.

10. Current evidence of cardiovascular risk including any of the following:

- LVEF

- A QT interval corrected for heart rate using the Bazett's formula greater or
equal to 480 msec;

- Clinically significant uncontrolled arrhythmias

- Acute coronary syndromes (including myocardial infarction and unstable angina).

- Congestive heart failure ≥ Class II as defined by New York Heart Association

11. Not able to understand and to comply with treatment instructions and requirements.