Morbidity, mortality and progress depends on systemic inflammation especially in ARDS patients. Previous studies claims that the proportion of mean platellet volume to platellet which can simply be determined with simple blood tests that are performed at admission, might predict the mortality in ARDS patients. Covid-19 pneumonia has a very similar clinical outlook with ARDS. Therefore we decided to research whether that proportion is legitimate for detecting the progress of Covid-19 pneumonia or not.
Covid-19 pneumonia is a spesific disease dispate its similarity to ARDS. There are nomorous
of studies that MPV/PLT ratio can predict the mortality, morbidity and the progress of ARDS.
Depending on the similarity of ARDS, MPV/PLT ratio might predict the clinical progress of
Covid-19 pneumonia. We retrospectively recruited150 patients admitted to our institute -a
tertiary center- with Covid-19 pneumonia to our study. Clinical based defining research, by
March-May 2020, the patients over 18 years old who were in either intensive care or ward
scanned retrospectively. The laboratory tests, chronic diseases , age and gender has been
collected from the written resources and electronic data retrospectively.
the patients who are diagnosed with Covid*19 pneumonia will be divided into two groups. The
ones in the ward will be considered as mild clinical course, and the ones in the intensive
care unit will be considered as severe clinical course. there will be an additional non Covid
individuals as a control group, which will consist 52 patients each. The ratio of MPV to PLT
will be calculated using admission hemogrames of these groups, and the significance of the
statistical differences on determining the prognosis of the disease will be discussed.
Gpower 3 for Mac Os (Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009). Statistical
power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behavior
Research Methods, 41, 11491160.) was used for istatistical power analysis.It was done using
ANOVA test between at least two independent groups. In order to provide enoughsample
magnitude power, which is 0.8, it was calculated that each group should have 52 patients
which makes at total of 156.
The normal distribution of data will be evaluated using Kolmogorov-Smirnov test. Parametric
ones will be used in normal distrubitions, non-parametric ones will be uused in abnormal
distrubitions. Between the independent groups, MPV/PLT ratio will be calculated using ANOVA
test. Categoric data will be compared by Pearson ki square test and the p values less than
0.05 will be considered as significant.
we aim to have an opinion about Covid 19-pneomonia prognosis at the admission of hospital.
Other: observation of covid 19 pneumonia
We try to reveal the fact,covid-19 pneumonia prognosis can be estimated by using MPV/PLT ratio
Inclusion Criteria:
- Patients over 18 years old who hospitalized with diagnosis of Covid-19 pneumonia
between march and may 2020
Exclusion Criteria:
- Under 18 years old patients
- Patients with heamolytic diaseses
Gaziosmanpaşa TREH
Istanbul, Gaziosmanpaşa, Turkey
Investigator: aygen türkmen, MD.prof.
Contact: +902129453000
aygenturkmen@hotmail.com
Investigator: zuhal çavuş, MD