Multi-centre prospective study evaluating computed tomography angiography studies performed for stroke patients as a diagnostic and prognostic imaging biomarker.
Diagnosis of coronavirus disease 2019 (COVID-19) relies on clinical features and
reverse-transcriptase polymerase chain reaction (RT-PCR) testing. The latter is constrained
by limited sensitivity and a timescale of hours to yield results, with no point-of-care test
widely available. A dedicated computed tomography study of the chest is likely to be more
sensitive than RT-PCR for COVID-19. Carotid computed tomography angiography (CTA) is a
routine acute stroke investigation and includes the lung apices. We aim to assess the lung
apices on CTA for ground glass opacification and compare this with COVID-19 RT-PCR test
results and clinical outcome measures.
Inclusion Criteria:
All adult patients presenting with clinical features of acute ischaemic stroke undergoing
investigation with computed tomography angiography at presentation.
Exclusion Criteria:
Poor image quality. No radiologist report available. Computed tomography angiography
performed in a non-acute setting.
Royal United Hospitals Bath NHS Foundation Trust
Bath, United Kingdom
North Bristol NHS Trust
Bristol, United Kingdom
University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom
Frimley Health NHS Foundation Trust
Camberley, United Kingdom
Cardiff and Vale University Health Board
Cardiff, United Kingdom
University Hospitals Coventry and Warwickshire NHS Trust
Coventry, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
Imperial College Healthcare NHS Foundation Trust
London, United Kingdom
King's College Hospital NHS FT (KCH)
London, United Kingdom
King's College Hospital NHS FT (PRUH)
London, United Kingdom
University College London NHS Foundation Trust
London, United Kingdom
Nathan Chan, FRCR
+44(0)7508192126
covidsalesresearch@gmail.com
Tom Booth, FRCR
+44(0)2032993279
thomas.booth@kcl.ac.uk