In December 2019, a new virus emerged in Wuhan, China rapidly becoming a pandemic with registered cases above 800,000 around the world. The virus is now known as SARS-CoV2 calling its disease coronavirus-19 or COVID-19. The mortality of the virus has been reported around 2-10% and its causes because of the proinflammatory immune response generated on the host. The cytokines involved in the immune response to COVID-19 are IL-1, IL-2, IL4, IL-6, IL-10, IL-12, IL-13, IL-17, GCSF, MCSF, IP-10, MCP-1, MIP-1α, HGF, IFN-γ y TNF-α. Ruxolitinib is an inhibitor of JAK 1/2 which is responsable for multiple cellular signals including the proinflammatory IL-6. Ruxolitinib works as and immunomodulator decreasing the cytotoxic T lymphocytes and increasing the Treg cells. This study is intended to stop the disregulated immune response caused by COVID-19 that generates the pneumonia and subsequent severe acute respiratory syndrome.
Drug: Ruxolitinib Oral Tablet
Ruxolitinib 5 mg twice a day
Inclusion Criteria:
- Patients with diagnosed COVID-19 with confirmatory test
- Increase in work of breathing or presence of dyspnea
- Presence of lung changes associated with COVID pneumonia by chest imaging
- Informed consent
Exclusion Criteria:
- Pregnancy or breastfeeding
- Thrombocytopenia below 20,000 cells/mm3
- Neutropenia below 500 cels/mm3
- Known and active infection of HIV, Hepatitis C, Hepatitis B, Herpes Zoster or
Mycobacterium Tuberculosis
Grupo Cooperativo de Hemopatías Malignas
Huixquilucan, Estado De México, Mexico