Background: Fatigue is among the most common symptoms of the long-term effects ofcoronavirus (long COVID). This study aims to compare the effectiveness of osteopathicmanipulative treatment (OMT) combined with physiotherapy treatment (PT) compared to PTalone on fatigue and functional limitations after two months post randomization in adultswith long COVID.Methods: This is a study protocol for a two-arm, assessor-blinded, pragmatic randomizedcontrolled superiority trial. Seventy-six participants will be randomly allocated toOMT+PT or PT. The PT includes usual care interventions including motor and respiratoryexercises targeting cardiorespiratory and skeletal muscle functions. The OMT entailsdirect, indirect, visceral, and cranial techniques. Patients will be evaluated before andafter a 2-month intervention program, and at 3-month follow-up session. Primaryobjectives comprise fatigue and functional limitations at 2-month post randomization asassessed by the fatigue severity scale and the Post-COVID Functional State scale.Secondary objectives comprise fatigue and functional limitations at 3 months, and theperceived change post-treatment as assessed by the Perceived Change Scale (PCS-patient).

To explore the efficacy of treatment of pulmonary cytokine storm induced by SARS-CoV2with a monoclonal antibody to IL-2 (Basiliximab) in addition to current standard of carevs current standard of care with the primary efficacy endpoint being the proportion ofsubjects alive and free of ventilator support, defined as intubation and requiringmechanical ventilation, at Day 28 from time of randomization.

The objective of the COVID-19 International Drug Pregnancy Registry (COVID-PR) is toevaluate obstetric, neonatal, and infant outcomes among women treated with monoclonalantibodies or antiviral drugs indicated for mild, moderate, or severe COVID-19 from thefirst day of the last menstrual period (LMP) to end of pregnancy. For monoclonalantibodies, the exposure period also includes 90 days prior to the first day of the LMP.

The 2020 COVID-19 pandemic, which began spreading on January 24, 2020 in France, hasrequired a profound and rapid reorganization of the health system, based in particular oninternal hospital reorganizations of front-line establishments, deprogramming ofnon-urgent activities, and transfers of non-covid19 patients to 2nd line facilities.Beyond the immediate impact on the management of patients infected with COVID-19, thisreorganization may have reduced the capacity of management for patients requiring urgentor semi-urgent intervention, or may have postponed some necessary care. The isolation ofpatients at home may also have resulted in lower compliance to therapy and medicaltreatments and may have contributed to decompensation.At the end of this crisis, the different organizational responses in France should beevaluated to identify the consequences and the areas for improvement in order to beprepared for future exceptional health situations. This investigation on healthcaresystems confronted to an exceptional health situation thus seeks to determine if theprofound reorganizations implemented during this health crisis have indirect effects onthe performance of care, in particular if there is a destabilization of the care systems(emergency, semi-emergency and chronic), a loss of chance for the patients and ifinnovative care paths have emerged.

Study Design: This is a double-blind, placebo-controlled, Phase 3 clinical efficacy studyevaluating NONS in adult volunteers as a treatment for high-risk asymptomatic andsymptomatic individuals with mild COVID-19 infection. thru facility).

The study aims to investigate (1) if COVID-19 vaccine impacts on blood pressure, (2) theextent of impact on blood pressure (if any), and (3) which groups of subjects are moresusceptible to be affected by COVID-19 vaccine on blood

To investigate short-term effect of COVID-19 vaccination on blood pressure by conducting24-hour ABPM

Coronavirus disease 2019 (COVID-19) which is caused by the virus Severe Acute RespiratorySyndrome Coronavirus-2 (SARS-CoV-2) has resulted in an ongoing global pandemic. It isunclear whether the relatively low number of reported cases of COVID-19 in people with CF(pwCF) is due to enhanced infection prevention practices or whether pwCF have protectivegenetic/immune factors. This study aims to prospectively assess the proportion of pwCF,including both adults and children with CF who have evidence of SARS-CoV-2 antibodiesover a two-year period. This study will also examine whether pwCF who have antibodies forSARS-CoV-2 have a different clinical presentation and what impact this has on their CFdisease. The proposed study will recruit pwCF from paediatric and adult CF centresthroughout the United Kingdom. Serological testing to detect antibodies will be performedon blood samples taken at month 0, 6, 12, 18 and 24 with additional time-points ifbloodwork is available via normal clinical care. Clinical data on, lung function,CF-related medical history, pulmonary exacerbations, antibiotic use, and microbiology andvaccination receipt, will be collected during routine clinical assessments.Associations will be examined between socio-demographic and clinical variables andserologic testing. The investigators will also examine the effects of SARS-CoV-2infection on clinical outcomes and analyse end-points to explore any age-related orgender-based differences, as well as subgroup analysis of outcomes in lung-transplantrecipients and pwCF receiving cystic fibrosis transmembrane conductance regulator (CFTR)modulator therapies. As pwCF receive COVID-19 vaccination the investigators will performa comparison of the development and progression of anti-SARS-CoV-2 antibodies in pwCFfollowing natural infection and vaccination SARS-CoV-2 over time.

To measure the immunization rate (seroneutralization) in a population of exposed hospitalworkers (nursing staff assigned to dedicated COVID-19 care units, laboratory staffhandling COVID-19 samples).

SATS is a single site feasibility study to assess the practical and psychologicalfeasibility of using rapid COVID antibody testing of blood obtained from fingertippin-pricks.